ALEVE® VS HYD+APAP
In a single-dose dental study, Aleve® was as strong† on pain as hydrocodone plus acetaminophen (HYD+APAP) and longer lasting.4
†In hours 0 to 4 of a single-dose dental study of Aleve® (440 mg), HYD+APAP (10 mg + 650 mg), or placebo.
ALEVE® VS HYD+APAP
In a single-dose dental study, Aleve® was as strong† on pain as hydrocodone plus acetaminophen (HYD+APAP) and longer lasting.4
†In hours 0 to 4 of a single-dose dental study of Aleve® (440 mg), HYD+APAP (10 mg + 650 mg), or placebo.
ALEVE® vs A DIFFERENT OPIOID COMBINATION
In 2 separate, single-dose dental studies, Aleve® was as strong on pain as acetaminophen plus codeine and longer lasting.5
ALEVE® vs A DIFFERENT OPIOID COMBINATION
In 2 separate, single-dose dental studies, Aleve® was as strong on pain as acetaminophen plus codeine and longer lasting.5
ALEVE® vs TYLENOL®
Aleve® was proven more effective‡ and provided longer lasting pain relief than Tylenol®.2,3
‡Based on clinical data from the first 6 hours after initial dosing.
ALEVE® vs TYLENOL®
Aleve® was proven more effective‡ and provided longer lasting pain relief than Tylenol®.2,3
‡Based on clinical data from the first 6 hours after initial dosing.
ALEVE® vs IBUPROFEN
In 2 identical, nonprescription dose studies in patients with OA of the knee, Aleve® provided more effective relief of pain at night than ibuprofen.6§
§Patients with mild to moderate OA of the knee were randomized to daily doses of naproxen sodium 660 mg, naproxen sodium 440 mg, ibuprofen 1200 mg, or placebo.
ALEVE® vs IBUPROFEN
In 2 identical, nonprescription dose studies in patients with OA of the knee, Aleve® provided more effective relief of pain at night than ibuprofen.6§
§Patients with mild to moderate OA of the knee were randomized to daily doses of naproxen sodium 660 mg, naproxen sodium 440 mg, ibuprofen 1200 mg, or placebo.
- Aleve® provided significant pain relief across all efficacy endpoints (P<0.05)‖
- Aleve® also provided significantly greater pain relief¶ for patients ≥65 years of age (P<0.05))‖ for:
- Pain on passive motion
- Pain during the day and pain at night
- Pain on weight bearing
- Proven efficacy across multiple studies
- Aleve® provided significant pain relief across all efficacy endpoints (P<0.05)‖
- Aleve® also provided significantly greater pain relief¶ for patients ≥65 years of age (P<0.05))‖ for:
- Pain on passive motion
- Pain during the day and pain at night
- Pain on weight bearing
- Proven efficacy across multiple studies
‖Results of a post hoc pooled analysis evaluating the efficacy and safety of Aleve® for short-term use in patients with OA of the knee or hip. In 4 multicenter, multidose, randomized, parallel, double-blind, placebo-controlled studies, Aleve® (age-based dosing regimen: <65 years, 660 mg/day; ≥65 years, 440 mg/day) or placebo was administered over 7 days. Data at baseline and after 7 days in 818 patients who received Aleve® or placebo (n=409 in each group) were pooled and analyzed.1
¶Compared with placebo.
OA = osteoarthritis
References: 1. Couto A, Troullos E, Moon J, Paredes-Diaz A, An R. Analgesic efficacy and safety of non-prescription doses of naproxen sodium in the management of moderate osteoarthritis of the knee or hip. Curr Med Res Opin. 2018;34(10):1747-1753. doi:10.1080/03007995.2018.1437029 2. Kiersch TA, Halladay SC, Hormel PC. A single-dose, double-blind comparison of naproxen sodium, acetaminophen, and placebo in postoperative dental pain. Clin Ther. 1994;16(3):394-404. 3. Daniels SE, Paredes-Diaz A, An R, Centofanti R, Tajaddini A. Significant, long-lasting pain relief in primary dysmenorrhea with low-dose naproxen sodium compared with acetaminophen: a double-blind, randomized, single-dose, crossover study. Curr Med Res Opin. 2019;35(12):2139-2147. doi:10.1080/03007995.2019.1654987 4. Cooper SA, Desjardins PJ, Bertoch T, et al. Analgesic efficacy of naproxen sodium versus hydrocodone/acetaminophen in acute postsurgical dental pain: a randomized, double-blind, placebo-controlled trial. Postgrad Med. 2021. doi:10.1080/00325481.2021.2008180 5. Data on file. Bayer Consumer Health. 6. Schiff M, Minic M. Comparison of the analgesic efficacy and safety of nonprescription doses of naproxen sodium and ibuprofen in the treatment of osteoarthritis of the knee. J Rheumatol. 2004;31(7):1373-1383. 7. Brophy RH, Fillingham YA. AAOS Clinical Practice Guideline Summary: Management of osteoarthritis of the knee (non-arthroplasty). J Am Acad Orthop Surg. 2022;30(9):e721–e729. doi:10.5435/JAAOS-D-21-01233. Accessed October 16, 2025. https://journals.lww.com/jaaos/Fulltext/2022/05010/AAOS_Clinical_Practice_Guideline_Summary_.10.aspx 8. Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res (Hoboken). 2020;72(2):149-162. doi:10.1002/acr.24131